Job Details

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok (https://www.tiktok.com/@abbvie) .

Job Description

Discovery Biotherapeutics at AbbVie is seeking a highly motivated Principal Research Scientist to lead a dynamic team supporting biologics drug discovery and engineering. The candidate will leverage expertise to develop and implement research plans for antibody identification/optimization supporting all AbbVie’s therapeutic areas. The ideal candidate should have extensive experience with in vitro display technologies for therapeutic discovery and engineering, a proven track record generating novel synthetic libraries, and project leadership to advance early- and late-stage discovery programs. They should possess excellent communication skills, be comfortable presenting in group settings, and having experience managing teams of 4 or more scientists. The applicant should be an enthusiastic creative scientist who will make tangible contributions to the continuous improvement and innovation within the organization.

Key Responsibilities:

• Lead a team applying in vitro display technologies for biotherapeutics discovery and engineering to support all AbbVie therapeutic areas

• Implement novel selection strategies and build industry-leading libraries for discovery and screening of therapeutic candidates

• Identify and solve technical problems independently, conceive and implement innovative research ideas

• Evaluate and integrate state-of-the-art technology to improve therapeutic discovery platforms, and demonstrate creative “out-of-the-box” thinking to solve difficult problems

• Ensure consistency and quality of technical reports from employees supervised

• Lead one or more teams, and influence areas in own discipline within department

• Provide project updates, analyses and advice to cross-functional teams and senior management

• Present original work internally across departments and at internal and external scientific conferences; may author or co-author peer-reviewed scientific papers or patents

• Supervise a team of 5+ scientists, evaluate team performance, and is accountable for the effective performance of team

• Act as subject matter expert, support and contribute to implementing and improving current workflows

• Ability to engage internal and external scientific leaders in collaborative research

• Serve as a biologics lead for cross-functional teams, and contribute scientific insights into multiple projects across various therapeutic areas; recognized and sought out as an expert in discovery and engineering of therapeutic molecules

Qualifications

• PhD, MS, or BS degree in Biochemistry, Biochemical engineering or related disciplines with typically 6+ (PhD), 12+ (MS), or 14+ (BS) years of experience in in vitro display technologies and applications to discover and engineer therapeutic proteins

• Sound scientific understanding of current state of in vitro antibody discovery

• Experience leading a team in discovery and/or engineering of diverse protein therapeutic formats

• Deep understanding of antibody structure and function

• Extensive experience and up-to-date knowledge in antibody engineering and optimization (e.g., humanization, Fc optimization) best practices

• Ability to explore and develop new approaches to further advance innovative in vitro discovery and screening technologies

• Background in biophysical and structural characterization of antibodies, fragments, and other binding domains

• Extensive experience in design and construction of novel antibody, fragment, and mimetic libraries

• Experience with bacterial toxin structure-function, stability, preferred

• Experience in display of complex proteins [non-antibody-like] preferred

• Experience with viral antigens and vaccine design, preferred

• Excellent organizational skills and the ability to manage multiple projects simultaneously

• Team player with the ability to operate in a fast-paced multi-disciplinary environment

• Adapt to rapid changes in project priorities and timelines

• Recognized in the scientific community through a sustained record of peer-reviewed publications and patents preferred

• Candidate must be a goal-oriented team player with excellent verbal and written communication skills, strong can-do attitude and experience in leading or managing teams

Key AbbVie Competencies:

• Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance.

• Learns fast, grasps the “essence” and can change the course quickly where indicated.

• Raises the bar and is never satisfied with the status quo.

• Creates a learning environment, open to suggestions and experimentation for improvement.

• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ?

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.?

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.?

• This job is eligible to participate in our short-term incentive programs. ?

• This job is eligible to participate in our long-term incentive programs?

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html

Salary: $121,000 - $230,000